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 Thyroid disease and Thyroxine

Thyroxine

Thyroxine (T4) is a vital hormone secreted by the thyroid gland located in front of the neck, and it regulates the Basal Metabolic Rate (BMR). The active form of thyroxine is called triiodothyronine (T3), which is made from thyroxine in the liver and kidneys. For this conversion of T4 to T3 one needs selenium, zinc and amino acid cysteine. However, to remove any confusion we will discuss thyroxine as the main thyroid hormone. Thyroxine is made from amino acid tyrosine and iodine in the thyroid gland. However, vitamins A, B group especially B2, B6, B12, vitamins C and E play an important role in this production. Without your thyroxine you would be feeling cold, lethargic, unmotivated, lazy and basically miserable. You would be overweight, have rough and dry skin, be constipated, have irregular periods, low libido, and be depressed. Thyroxine gives you vitality and energy. It aids the protein synthesis, which is necessary for enzyme production and hence affecting many functions in the body. Thyroid hormone is vital in bone growth, heart function, development of the nervous system, enhancement of immune system, lipid metabolism, prevention of osteoporosis, and the rate of absorption of nutrients via gastrointestinal tract. Without thyroxine one would age much faster.

In any anti-aging program the thyroid function tests including TSH (Thyroid Stimulating Hormone), T4, T3 and RT3 (Reversed T3) should be measured and treated in case of deficiency. Stress should be dealt with as it produces cortisol which blocks T4 to T3 conversion.

Reversed T3 syndrome

When RT3 is above the normal range it produces some features of hypothyroidism. These include lethargy, slow heart beat, low body temperature, feeling cold, horse voice, coarse skin, slow speech, slow thinking, obesity and constipation. Increased RT3 inhibits the action of T3.

Stress, high cortisol level, fasting, illness and low zinc and selenium levels cause Reversed T3 syndrome as they block conversion of T4 to T3.

To treat this condition one needs to treat the underlying cause, supplement with zinc and selenium in deficient patients and bring T3 into balance.

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